IVIG dupes? Swaps that surpass results! Treat PANS at home

PANS / PANDAS Awareness Day is today, October 9. To all parents living with challenges, we are walking alongside and here to support you.

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If you’ve ever weighed IVIG, you’ve likely also hit some walls: an anxious child, stories of brief gains that fade, side effects, relapses, insurance denials and cost obstacles.

You might be relieved to know parents can copy the mechanisms that make IVIG helpful and replicate them conveniently at home.

We will give you the direct map that can:

reduce what’s provoking the immune system
calm innate fire and microglia,
prevent collateral damage,
repair barriers,
regulate immune function,
and give cells enough energy to hold the calmer pattern.

What IVIG is doing when it helps → the matching swap

1. Lowering immune “noise” and calming microglia / innate fire → KPV

KPV turns down NF‑kB cytokines and steadies mast cells so brain immune cells can stand down.
- After triggers, parents see faster settling or no flare at all.
- Approx start: a very small sprinkle, about 1/20 to 1/10 capsule per dose, 2 to 4 times daily.
- See this post for more on KPV.
- Bacterial & fungal die off can be a concern when starting KPV. See this detox post. Or consider instead starting with the gentler, Plavelle.

2. Tilting toward regulation so spikes resolve faster → Selank

Selank reduces anxiety and supports flexibility / calmer responses so stress and transitions don’t reignite the loop.
- This is the “don’t let it spiral” piece.
- It also has antiviral properties and can help prevent flares from a viral trigger.
  - Use: 1 sublingual spray 1-2x daily (tailor to needs); onset in minutes, lasts hours.
  - See this post for more on Selank.

Just one of many incredible PANS wins with Selank

3. Holding the calmer pattern through the day → NAD+
(a step beyond what IVIG can do)

NAD+ is a small molecule that supports mitochondrial energy, helps calm mast cells, and lowers danger signaling – so the IVIG‑like calm you created with KPV and Selank can actually hold.
- 1 or 1/2 spray, sublingual AM, with food and TMG
- If it feels like too much energy, skip a day.
- See our NAD+ post for more info

Why some choose this path even when IVIG is available

IVIG helps when it lowers immune noise, calms microglia, and tilts the system toward resolution.

But it’s a major commitment and added stress which is the last thing PANS families need.

Some kids don’t respond to IVIG as hoped and too often results fade shortly afterward. New provocations keep the system stirred up, or cellular energy is too low to maintain the calmer set‑point.

Because IVIG is a blood product, pooled from thousands of donors, some families have concerns about possible viral or other exposures. There are also side effects to research.

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At home – with much less time, stress, expense, and risk, parents can achieve the benefits – without having them fade (and even improve over time)

To recap the the tools:

• KPV to lower the inflammatory signal

• Selank to support calm & regulation under stress, and

• NAD+ to help stability last by steadying mast cells and reducing danger signaling.

Sequence

All can be started around the same time. Beginning NAD+ and Selank prior to KPV can help any initial die off be more manageable.

Go low & slow with KPV & NAD+ even the smallest doses are very effective.

Dosing info page.

Purchasing info page.

A Parent Success story

For even more

You can find each of these within our broader PANS protocol <click to read.

This protocol has brought benefits greatly surpassing IVIG.

There are many children who are having no flares even when exposed to triggers.

What’s the difference?

In our longer posts, nuances are covered such as: aggression, acute illness (also at bottom of this page), and nervous system healing. We give simple, doable practices to lower background threat to heal even more efficiently.